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Allosteric pathways in the adenosine A2A receptor during G protein coupling

Cover illustration created for Prof. Scott Prosser from the Department of Chemical and Physical Sciences at the University of Toronto (2021)

Nuclear magnetic resonance spectroscopy of the A2A receptor complexed with heterotrimeric G protein revealed a pathway of ligand-dependant allosteric signal transmission, highlighted in this illustration.
Huang SK, Pandey A, Tran DP, Villanueva NL, Kitao A, Sunahara RK, Sljoka A, Prosser RS. Delineating the conformational landscape of the adenosine A2A receptor during G protein coupling. Cell. 2021 Apr 1;184(7):1884-1894.e14. doi:10.1016/j.cell.2021.02.041.

Audience: Expert scientists


Media: UCSF Chimera, Autodesk Maya, Adobe Illustrator, Adobe Photoshop