Structural basis of human separase regulation by securin and CDK1-cyclin B1
Cover illustration created for Prof. Andreas Boland from the Department of Molecular and Cell Biology at the University of Geneva (2021)
This study reveals how securin and CDK1-cyclin B1 bind and inhibit separase through pseudosubstrate autoinhibitory motifs. The ourobouros, an ancient symbol depicting a dragon eating its own tail, illustrates this concept of auto-inhibition.
Yu J, Raia P, Ghent CM, Raisch T, Sadian Y, Cavadini S, Sabale PM, Barford D, Raunser S, Morgan DO, Boland A. Structural basis of human separase regulation by securin and CDK1-cyclin B1. Nature. 2021 Aug;596(7870):138-142. doi: 10.1038/s41586-021-03764-0.
Audience: Expert scientists
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